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Risk of osteoporosis in breast cancer survivors: nutritional aspects
Vorudová, Jana ; Zikán, Vít (advisor) ; Matoulek, Martin (referee)
Introduction: Osteoporosis belongs to multifactorial metabolic skeletal disease. The breast carcinoma is one of the most common malignities in women worldwide (with an exception of skin tumours). Postmenopausal women with non-metastatic breast carcinoma, which are treated with aromatase inhibitors (AI), have increased risk of developing osteoporosis. In these patients, it is necessary to identify the factors contributing to onset of osteoporosis which can be influenced, and take protective measures towards bone metabolism, in order to reduce the occurrence of serious low-traumatic fractures. Objective: The objective of this thesis is to evaluate the diet with regard to risk factors leading to osteoporosis and bone fractures in postmenopausal women with breast carcinoma without metastases, which are treated with AI. Another objective for this group of women is to evaluate the changes of bone mineral density (BMD) and certain parameters of body composition during long-term treatment of AI. Methods: The present study is based on a questionnaire containing a table to quote a three day diet, which was subsequently analysed to identify the overall energetic income, the income of proteins, fat, carbohydrates, dietary fibre and calcium. The supply of vitamin D was deduced for the serum concentration of...
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